HPLC of structural isomers with cyclodextrin-poly(vinylamine)-coated silica columns, Part I: Synthesis and characterization of cyclodextrin-bonded stationary phases by NMR solid state.

Different supports for high-performance liquid chromatography are prepared by using the coating technology. These supports are based on silica beads coated with a beta-cyclodextrin-containing poly(vinylamine). Surface area, pore size distribution, and solid-state nuclear magnetic resonance are used for the characterization of these supports. The two different methods of preparation used lead to different arrangements of the polymer layers; hence, the supports have different mobility, rigidity, and accessibility of the cyclodextrin ring.